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KMID : 1144820190250010054
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대한의생명과학회지
2019 Volume.25 No. 1 p.54 ~ p.59
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Anti-inflammatory Modulating Effect of Rengyolone in Rat
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Lee Gil-Hyon
Hyun Kyung-Yae
Kang Yoon-Jung
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Abstract
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Hepatitis refers to inflammation of hepatocytes and liver tissue, and is mainly caused by viruses, alcohol, and drugs. Forsythiae Fructus has traditionally been used as a diuretic, anti-inflammatory and antipyretic. Research on rengyolone, a bioactive substance extracted from Forsythiae Fructus, is rarely found in Korea and abroad. First, an acute animal toxicity test for rengyolone was conducted for the animal experiment. 4 week-old SD rats were injected intraperitoneally with acetaminophen for 2 weeks to induce chronic liver inflammation. Rengyolone was orally administered into two groups during 4 weeks: pre-inflammatory group and post-inflammatory group. Oral doses were also divided into 1 mg/kg and 5 mg/kg. Liver function tests (ALT, AST, ALP), western blot analysis of liver tissue, and level of inflammatory cytokine were performed to evaluate the improvement of hepatitis. Experimental results showed that rengyolone inhibited the development of acute inflammation and thus could reduce hepatitis symptoms.
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KEYWORD
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Hepatitis, Forsythiae fructus, Rengyolone, Acetaminophen, Liver function tests, iNOS
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